Martin-Luther-Universität Halle-Wittenberg

Innenhof des Biologicums am Weinbergcampus in Halle

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Prof. Dr. Karsten Mäder

Martin-Luther-Universität Halle-Wittenberg
Institute of Pharmacy
Wolfgang-Langenbeck-Str. 4 (Raum 135)
06120 Halle (Saale)

Telefon: +49 345 552-5167
Fax:       +49 345 552-7029

E-Mail:

Link bereits bestehender Homepage:
http://pharmtech.pharmazie.uni-halle.de

Funktionen

Leiter Institutsbereich Pharmazeutische Technologie / Biopharmazie

Stellvertretender Institutsdirektor Institut für Pharmazie, Naturwiss. Fakultät I, MLU Halle-Wittenberg

Mein Interesse an der Alternsforschung

Verbesserung der Arzneimitteltherapie altersbedingter Krankheiten.

Forschungsschwerpunkte

Zielgerichteter Wirkstofftransport und Wirkstoffaktivierung, Drug Delivery Systeme, Tumortherapie

Ausgewählte Projekte

pH- und redoxaktivierte Wirkstoffreisetzung für Tumore

In situ Implantate

Entwicklung neuer Polymer- und Lipidimplantate zur Tumortherapie

5 ausgewählte Publikationen der letzten 5 Jahre

A. Schädlich, S. Kempe, K. Mäder:
Non-invasive in vivo characterization of microclimate pH inside in situ forming PLGA implants using multispectral fluorescence imaging.
Journal of Controlled Release, 179, 52–62 (2014).

P. Chytil, S. Hoffmann, L. Schindler, L. Kostka, K. Ulbrich, H. Caysa, T. Mueller, K. Mäder and T. Etrych:
Dual Fluorescent HPMA Copolymers for Passive Tumor Targeting with pH-Sensitive Drug Release: Impact of Release Rate on Biodistribution.
Journal of Controlled Release, 172, 504-512 (2013).

A. Hill, S. Geißler, M. Meyring, S. Hecht, M. Weigandt and K. Mäder:
In-Vitro-In-Vivo evaluation of nanosuspension release from subcutaneously implantable osmotic pumps.
International Journal of Pharmaceutics, 451, 57– 66 (2013).

S. Hoffmann, H. Caysa, J. Kuntsche, P. Kreideweiß, A. Leimert, T. Müller, K. Mäder:
Carbohydrates for Passive Tumor Targeting: In Vivo Studies and Size Distribution Characterisation In Vitro and In Vivo Studies.
Carbohydrate Polymers, 95, 404-413 (2013).

A. Hill, S. Breyer, S. Geissler, W. Mier, U. Haberkorn, M. Weigandt, K. Mäder:
How do in-vitro release profiles of nanosuspensions from Alzet® pumps correspond to the in-vivo situation? A case study on radiolabeled fenofibrate.
Journal of Controlled Release, 168, 77-87 (2013).

V.M. Weiss, T. Naolou, T. Groth, J. Kressler, K. Mäder:
In vitro toxicity of stearoyl-poly(glycerol adipate) nanoparticles.
J. Appl. Biomater. Function Mater., 10 (3), 163-169 (2013).

H. Caysa, S. Hoffmann, J. Luetzkendorf, L.P. Mueller, S. Unverzagt, K. Mäder, T. Mueller:
Monitoring of xenograft tumor growth and response to chemotherapy by non-invasive in vivo multispectral fluorescence imaging.
PloS ONE, 7(10):e47927, (2012).

S. Kempe, K. Mäder:
In situ forming implants - an attractive formulation principle for parenteral depot formulations.
Journal of Controlled Release 161, 668-679 (2012).

A. Schädlich, S. Hoffmann, T. Mueller, H. Caysa, C. Rose, A. Göpferich, J. Li, J. Kuntsche, K. Mäder:
Accumulation of nanocarriers in the ovary: a neglected toxicity risk?
Journal of Controlled Release 160, 105–112 (2012).

S. Hoffmann, L. Vystrcilova, K. Ulbrich, T. Etrych, H. Caysa, T. Mueller, K. Mäder:
Dual Fluorescent HPMA Copolymers for Passive Tumour Targeting with pH-Sensitive Drug Release: Synthesis and Characterisation of Distribution and Tumour Accumulation in Mice by Noninvasive Multispectral Optical Imaging.
Biomacromolecules, 13, 652–663 (2012).

A. Hill, S. Geißler, M. Weigandt, K. Mäder:
Controlled delivery of nanosuspensions from osmotic pumps: Zero order and non-zero order kinetics.
Journal of Controlled Release, 158, 403-412 (2012).

V.M. Weiss, T. Naolou, G. Hause, J. Kuntsche, J. Kressler, K. Mäder:
Poly(glycerol adipate)-fatty acid esters as versatile nanocarriers: From nanocubes over ellipsoids to nanospheres.
Journal of Controlled Release, 158, 156–164 (2012).

V.M. Weiss, T. Naolou, E. Amado, K. Busse, K. Mäder, J. Kressler:
Formation of Structured Polygonal Nanoparticles by Phase-separated Comb-like Polymers. Macromolecular Rapid Communications, 33, 35−40 (2012).

A. Schädlich, H. Caysa, T. Mueller, F. Tenambergen, C. Rose, A. Göpferich, J. Kuntsche, K. Mäder:
Tumor accumulation of NIR fluorescent PEG-PLA nanoparticles: Impact of particle size and human xenograft tumor model.
ACS Nano 5, 8710–8720 (2011).

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