Martin-Luther-Universität Halle-Wittenberg

Innenhof des Biologicums am Weinbergcampus in Halle


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Metabolic Programming

Metabolic programming: Role of insulin, IGFs, adipokines and microRNA networks on trophoblast and placental development


  • Januar 2008 bis Dezember 2009


  • Prof. Dr. Dr. Bernd Fischer


  • Dr. Anne Navarrete Santos


  • Professor Julie A. Owens, Dr. Claire Roberts, School of Paediatrics and Reproductive Health, Discipline of Obstetrics and Gynaecology, University of Adelaide, AUS


  • DAAD D/07/15753
  • 10.321 €


Insulin and IGFs are of prime significance for embryologists. They are key regulators of embryo metabolism and decisive determinants for metabolic programming. In a cooperative approach (UA, MLU) the developmental impact of insulin and IGFs will be studied on metabolic pathways in preimplantation mouse and rabbit embryos and on trophoblast stem cell differentiation and placentation. Transfer of up-to-date methodology, established in the partners’ laboratories, will be realised by hands-on training of early career researchers and exchange of senior investigators.


  • Fischer, B., Navarrete Santos A. (2003) Glukose, Insulin und Glukosetransporter: Bedeutung und Weichenstellungen für die Embryonalentwicklung. Reproduktionsmedizin 19, 195-201
  • Navarrete Santos, A., Tonack, S., Kirstein, M., Kietz, S., Fischer, B. (2004) Two insulin-responsive glucose transporter isoforms and the insulin receptor are developmentally expressed in rabbit preimplantation embryos. Reproduction 128, 503-516
  • Navarrete Santos, A., Tonack, S, Kirstein, M., Pantaleon, M., Kaye, P., Fischer, B. (2004) Insulin acts via MAPK phosphorylation in rabbit blastocysts. Reproduction 128, 517-526
  • Tonack, S., Rolletschek, A., Wobus, A., Fischer, B., Navarrete Santos, A. (2006) Differential expression of glucose transporter isoforms during embryonic stem cell differentiation. Differentiation 74, 499-509
  • Navarrete Santos, A., Ramin, N., Sarah Tonack, S., Fischer, B. (2008) Cell lineage-specific signalling of insulin and insulin like growth factor (IGF) 1 in rabbit blastocysts. Endocrinology 149, 515-524

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